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Description of Additional Supplementary Files

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While her parents have kept her out of the spotlight, Webster occasionally makes rare appearances on her parents’ social media accounts. Anastasia Radzinskaya, popularly known by her online name, Like Nastya, might be the richest teenager who is not royalty or a heiress. The nine-year-old host has multiple YouTube channels with her parents, focusing on children’s stories, roleplays, and similar content. Mia Talerico is a teenage actress who first appeared in the Disney Channel sitcom Good Luck Charlie at the age of 11 months in 2010.

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• PRR11 blocks p85 homodimerization and sensitizes to ligand-induced PI3K activation, suggesting that PRR11 amplification confers resistance to estrogen deprivation through hyperactivation of the PI3K pathway.

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Transduction of PRR11 into MDA-MB-134VI and MDA-MB175VII cells attenuated growth inhibition by fulvestrant (Fig. 3h and Supplementary Fig. 3b). PRR11 knockdown re-sensitized fulvestrant-resistant (FulvR) MCF7 cells to fulvestrant (Fig. 3i and Supplementary Fig. 3c). A similar result was observed in tamoxifen-resistant (TamR) MCF7 and TamR HCC1428 cells (Supplementary Fig. 3d).

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Napoleon Hill explains that our brain is a remarkable machine and it works just like a broadcasting and receiving station for thoughts. With more than 14 million nerve cells, the brain works like a factor that guides and controls our day-to-day life. He also says that thoughts are things and the greater the vibration our brain receives, the higher the chances we can achieve our goals. This book is all about harnessing the power of your subconscious mind.

A.L. Guerrero-Zotano has received grant support from Pfizer and travel support from Pfizer and Roche. V.M. Jansen is a current employee and shareholder of Eli Lilly and Company. After 24 h from transfection with control siRNA or PRR11 siRNAs, HCC1428, and MCF7 (LTED, TamR, and FulvR) cells were seeded in 6-well plates. Cells were trypsinized and then counted every 3 days for 6 days. Number of cells were counted with Z2 coulter counter analyzer (Beckman coulter). Four-μm tissue sections were mounted on charged slides and hybridized overnight with a PRR11 FISH probe (EMPIRE GENOMICS) and a centromere 17 control probe (EMPIRE GENOMICS); FISH was performed as described previously14.

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